Zixuan Ding

Profile

We study how P-E interactions contribute to cell-type-specific gene regulation during zebrafish gastrulation. Using high-temporal-resolution scMultiome and computational methods like SCENIC+ and RegVelo, we infer TF–enhancer–effector gene regulatory modules and their role in cell fate decisions. We use Micro-Capture-C to dissect how enhancers/repressors/other elements interact with the promoter in those modules. Ongoing efforts include functional perturbation of TFs/CREs and using additional modalities to explain the mechanism.