Publications

Niche Tet maintains germline stem cells independently of dioxygenase activity

Tu R, Ping Z, Liu J, Tsoi ML, Song X, Liu W, Xie T. EMBO J. 2024;43:1570-1590.

Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal

Kandola T, Venkatesan S, Zhang J, Lerbakken B, Schulze AV, Blanck JF, Wu J, Unruh J, Berry P, Lange JJ, Box A, Cook M, Sagui C, Halfmann R. eLife 2023;12:RP86939. doi: 10.7554/eLife.86939.

DAmFRET measures saturating concentrations and toxicities of protein phase transitions in vivo

Miller T, Wu J, Venkatesan S, Gama AR, Halfmann R. Mol Biol Cell. 2023:mbcE22110503.

A nucleation barrier spring-loads the CBM signalosome for binary activation

Rodriguez Gama A, Miller T, Lange JJ, Unruh JR, Halfmann R. eLife. 2022;11:e79826. doi: 10.7554/eLife.79826.

Heat Therapy Can Improve Hepatic Mitochondrial Function and Glucose Control

Johnson CN, Jensen RS, Von Schulze AT, Geiger PC. [published ahead of print April 9 2022]. Exerc Sport Sci Rev. 2022.

The 2021 FASEB Virtual Science Research Conference on Protein Aggregation: Function, Dysfunction, and Disease, June 23-25, 2021

Hatters DM, Halfmann R, Baum J. T. FASEB J. 2021;35:e21884.

DNCON2_Inter: predicting interchain contacts for homodimeric and homomultimeric protein complexes using multiple sequence alignments of monomers and deep learning

Quadir F, Roy RS, Halfmann R, Cheng J. Sci Rep. 2021;11:12295. doi 10.1038/s41598-021-91827-7.

Mechanistic inferences from analysis of measurements of protein phase transitions in live cells

Posey AE, Ruff KM, Lalmansingh JM, Kandola TS, Lange JJ, Halfmann R, Pappu RV. [published ahead of print February 5 2021]. J Mol Biol. 2021:166848. doi: 166810.161016/j.jmb.162021.166848.

Mechanics of a molecular mousetrap-- nucleation-limited innate immune signaling

Rodriguez Gama A, Miller T, Halfmann R. Biophys J. 2021;120:1150-1160..

wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death

Nuckolls NL, Mok AC, Lange JJ, Yi K, Kandola TS, Hunn AM, McCroskey S, Snyder JL, Bravo Nunez MA, McClain M, McKinney SA, Wood C, Halfmann R, Zanders SE.  eLife. 2020;9:e55694. doi: 55610.57554/eLife.55694.

Detecting and Characterizing Protein Self-Assembly in vivo by Flow Cytometry

Venkatesan S, Kandola TS, Rodriguez-Gama A, Box A, Halfmann R. J Vis Exp. 2019;149:e59577. doi: 59510.53791/59577.

Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation

Holliday MJ, Witt A, Rodriguez Gama A, Walters BT, Arthur CP, Halfmann R, Rohou A, Dueber EC, Fairbrother WJ. Nat Commun. 2019;10:3070. doi: 10.1038/s41467-019-10953-z.

scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling

Lush ME, Diaz DC, Koenecke N, Baek S, Boldt H, St Peter MK, Gaitan-Escudero T, Romero-Carvajal A, Busch-Nentwich EM, Perera AG, Hall KE, Peak A, Haug JS, Piotrowski T.  Elife. 2019;8:e44431. doi: 44410.47554/eLife.44431.

Quantifying nucleation in vivo reveals the physical basis of prion-like phase behavior

Khan T, Kandola TS, Wu J, Venkatesan S, Ketter E, Lange JJ, Rodriguez Gama A, Box A, Unruh JR, Cook M, Halfmann R. Mol Cell. 2018;71:155-168.e157.

A self-perpetuating repressive state of a viral replication protein blocks superinfection by the same virus

Zhang XF, Sun R, Guo Q, Zhang S, Meulia T, Halfmann R, Li D, Qu F. PLoS Pathog. 2017;13:e1006253. doi: 1006210.1001371/journal.ppat.1006253.

A glass menagerie of low complexity sequences​

Halfmann R. Curr Opin Struct Biol. 2016;38:9-16.

Single-Cell Based Quantitative Assay of Chromosome Transmission Fidelity.

Zhu J, Heinecke D, Mulla W, Bradford WD, Rubinstein B, Box A, Haug JS, Li R. G3 (Bethesda). 2015.;5:1043-56.

Heparan Sulfate Proteoglycans Regulate Fgf Signaling and Cell Polarity during Collective Cell Migration.

Venero Galanternik M, Kramer KL, Piotrowski T. Cell Rep. 2015;10:414-428.