Publications
Publications
Niche Tet maintains germline stem cells independently of dioxygenase activity
Tu R, Ping Z, Liu J, Tsoi ML, Song X, Liu W, Xie T. EMBO J. 2024;43:1570-1590.
Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal
Kandola T, Venkatesan S, Zhang J, Lerbakken B, Schulze AV, Blanck JF, Wu J, Unruh J, Berry P, Lange JJ, Box A, Cook M, Sagui C, Halfmann R. eLife 2023;12:RP86939. doi: 10.7554/eLife.86939.
DAmFRET measures saturating concentrations and toxicities of protein phase transitions in vivo
Miller T, Wu J, Venkatesan S, Gama AR, Halfmann R. Mol Biol Cell. 2023:mbcE22110503.
A nucleation barrier spring-loads the CBM signalosome for binary activation
Rodriguez Gama A, Miller T, Lange JJ, Unruh JR, Halfmann R. eLife. 2022;11:e79826. doi: 10.7554/eLife.79826.
Heat Therapy Can Improve Hepatic Mitochondrial Function and Glucose Control
Johnson CN, Jensen RS, Von Schulze AT, Geiger PC. [published ahead of print April 9 2022]. Exerc Sport Sci Rev. 2022.
Hatters DM, Halfmann R, Baum J. T. FASEB J. 2021;35:e21884.
Quadir F, Roy RS, Halfmann R, Cheng J. Sci Rep. 2021;11:12295. doi 10.1038/s41598-021-91827-7.
Mechanistic inferences from analysis of measurements of protein phase transitions in live cells
Posey AE, Ruff KM, Lalmansingh JM, Kandola TS, Lange JJ, Halfmann R, Pappu RV. [published ahead of print February 5 2021]. J Mol Biol. 2021:166848. doi: 166810.161016/j.jmb.162021.166848.
Mechanics of a molecular mousetrap-- nucleation-limited innate immune signaling
Rodriguez Gama A, Miller T, Halfmann R. Biophys J. 2021;120:1150-1160..
wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death
Nuckolls NL, Mok AC, Lange JJ, Yi K, Kandola TS, Hunn AM, McCroskey S, Snyder JL, Bravo Nunez MA, McClain M, McKinney SA, Wood C, Halfmann R, Zanders SE. eLife. 2020;9:e55694. doi: 55610.57554/eLife.55694.
Detecting and Characterizing Protein Self-Assembly in vivo by Flow Cytometry
Venkatesan S, Kandola TS, Rodriguez-Gama A, Box A, Halfmann R. J Vis Exp. 2019;149:e59577. doi: 59510.53791/59577.
Holliday MJ, Witt A, Rodriguez Gama A, Walters BT, Arthur CP, Halfmann R, Rohou A, Dueber EC, Fairbrother WJ. Nat Commun. 2019;10:3070. doi: 10.1038/s41467-019-10953-z.
Quantifying nucleation in vivo reveals the physical basis of prion-like phase behavior
Khan T, Kandola TS, Wu J, Venkatesan S, Ketter E, Lange JJ, Rodriguez Gama A, Box A, Unruh JR, Cook M, Halfmann R. Mol Cell. 2018;71:155-168.e157.
Zhang XF, Sun R, Guo Q, Zhang S, Meulia T, Halfmann R, Li D, Qu F. PLoS Pathog. 2017;13:e1006253. doi: 1006210.1001371/journal.ppat.1006253.
A glass menagerie of low complexity sequences​
Halfmann R. Curr Opin Struct Biol. 2016;38:9-16.
Single-Cell Based Quantitative Assay of Chromosome Transmission Fidelity.
Zhu J, Heinecke D, Mulla W, Bradford WD, Rubinstein B, Box A, Haug JS, Li R. G3 (Bethesda). 2015.;5:1043-56.