News

09 April 2025
Stowers scientists use AI to decipher how cells respond to developmental cues
New study shows how we can better learn our genome’s hidden grammar, potentially paving the way for personalized medicine.
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Investigator Julia Zeitlinger, PhD, was awarded a four-year, approximately $2.3 million grant from the NIH’s National Human Genome Research Institute. This marks the first grant awarded to a Stowers scientist by this NIH institute.
Zeitlinger’s research focuses on how DNA sequence information in the genome controls gene regulation. The Zeitlinger Lab aims to develop breakthrough genomic techniques that will allow for the collection of “cis-regulatory” information. A cis-regulatory module is a stretch of DNA where a number of transcription factors can bind and regulate expression of nearby genes and regulate their transcription rates. However, scientists have encountered challenges with collecting and mapping cis-sequence information due to insensitive and sparse data.
Zeitlinger and her lab have developed a technique that will allow for improved data collection with smaller samples, eventually even as small as a single cell, yet with greater resolution and sensitivity. With better sampling technique and data collection, Zeitlinger hopes to improve the ability to study mammalian embryogenesis which may improve our understanding of development, evolution, and disease.
News
09 April 2025
New study shows how we can better learn our genome’s hidden grammar, potentially paving the way for personalized medicine.
Read Article
In The News
01 November 2024
From the Kansas City Business Journal, The Stowers Institute for Medical Research is turning to artificial intelligence to more rapidly make discoveries about human health and disease.
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