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Kostova Lab
How do changes in the ribosome promote health or drive disease?
Welcome to the Kostova Lab!
We are investigating the fundamental question of how cells respond when their ribosomes break down. The ribosome is one the most complex and long-lived molecular machines in the cell and the presence of functional ribosomes is essential to live. Ribosome damage has been recently linked to complex human diseases, such as cancer and neurodegeneration. We use cutting-edge technology, such as CRISPR-mediated genome editing and genome scale screens, to model and map the molecular pathways that ensure ribosome integrity.
Science offers endless opportunities for exploration and discovery. In the Kostova Lab we are committed to asking big questions that help uncover how broken ribosomes can facilitate disease initiation and progression.