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Publications

Origin of complexity in hemoglobin evolution

Pillai, Arvind S., Shane A. Chandler, Yang Liu, Anthony V. Signore, Carlos R. Cortez-Romero, Justin LP Benesch, Arthur Laganowsky, Jay F. Storz, Georg KA Hochberg, and Joseph W. Thornton. "Origin of complexity in haemoglobin evolution." Nature 581, no. 7809 (2020): 480-485.

De novo design of allosterically switchable protein assemblies

Pillai, Arvind, Abbas Idris, Annika Philomin, Connor Weidle, Rebecca Skotheim, Philip JY Leung, Adam Broerman et al. "De novo design of allosterically switchable protein assemblies." Nature 632, no. 8026 (2024): 911-920.

Simple mechanisms for the evolution of protein complexity

Pillai, Arvind S., Georg KA Hochberg, and Joseph W. Thornton. "Simple mechanisms for the evolution of protein complexity." Protein science 31, no. 11 (2022): e4449.

Symmetry facilitated the evolution of heterospecificity and high-order stoichiometry in vertebrate hemoglobin

Cortez-Romero, Carlos R., Jixing Lyu, Arvind S. Pillai, Arthur Laganowsky, and Joseph W. Thornton. "Symmetry facilitated the evolution of heterospecificity and high-order stoichiometry in vertebrate hemoglobin." Proceedings of the National Academy of Sciences 122, no. 4 (2025): e2414756122.

Ion binding with charge inversion combined with screening modulates DEAD box helicase phase transitions

Crabtree, Michael D., Jack Holland, Arvind S. Pillai, Purnima S. Kompella, Leon Babl, Noah N. Turner, James T. Eaton et al. "Ion binding with charge inversion combined with screening modulates DEAD box helicase phase transitions." Cell Reports 42, no. 11 (2023).

Design of stimulus-responsive two-state hinge proteins

Praetorius, Florian, Philip JY Leung, Maxx H. Tessmer, Adam Broerman, Cullen Demakis, Acacia F. Dishman, Arvind Pillai et al. "Design of stimulus-responsive two-state hinge proteins." Science 381, no. 6659 (2023): 754-760.